New limonoids and a furanone derivative from the fruits of Melia azedarach L
Two new limonoid analogues, meliazedatins A and B (1 and 2), and a new furanone, (5S)-4,5-dimethyl-5-hydroxymethyl-2(5H)-furanone (3), together with nine previously reported compounds, were separated from the ripe fruits of Melia azedarach L. Bioassays revealed that compound 3 exerted mild cytotoxic activity against HT-22 neuronal cells when treated at a dosage of 10 μM.
Authors
- YANG Sheng-He
- Jiaqi Li (ORCID: https://orcid.org/0009-0001-8222-5267)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0003-2486-1107)
- Yibing Wu (ORCID: https://orcid.org/0000-0003-4168-0295)
- Yan Fu
- Jia-Li Lang
Institutions
- Hebei Medical University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1080/14786419.2026.2753098
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00