Outcomes in Studies for Individuals Receiving Home Mechanical Ventilation: Scoping Review

Background Home mechanical ventilation (HMV) is a life-sustaining therapy for individuals with chronic respiratory failure. Despite a high morbidity and mortality of patients using HMV, few clinical trials inform practice. HMV-related research is impacted by the absence of a core outcome set (COS). This scoping review informs the development of a COS to be reported in interventional studies for individuals requiring HMV. Methods We conducted a scoping review including interventional and cohort studies recruiting adults and children receiving HMV. We searched six databases in March 2026, and conducted citation tracking of relevant studies. Study screening and data extraction were conducted independently in duplicate. We categorised outcomes using the Core Outcome Measures in Effectiveness Trials (COMET) 38-domain taxonomy, and assessed reporting quality using established criteria. Results Of 21 467 records screened, 287 studies were included: 78% adult, 18% paediatric, and 4% mixed populations. Studies evaluated HMV initiation (56%), patient interventions (31%), caregiver interventions (11%); or a combination of components (2%). We identified 71 distinct primary and 100 distinct secondary outcomes representing all COMET core areas. Primary outcomes were frequently in the respiratory, hospital, and mortality/survival domains, while respiratory, delivery of care, and global quality of life outcomes were predominant among secondary outcomes. Outcome reporting quality was high in 68% of studies. Conclusion Outcome selection in HMV studies is highly variable, supporting the need for a COS to improve consistency of future research informing clinical decision-making and policy.

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Journal
ERJ Open Research
Published
2026-10-29
DOI
https://doi.org/10.1183/23120541.00921-2026
Primary Topic
Respiratory Support and Mechanisms
Type
article
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article

Outcomes in Studies for Individuals Receiving Home Mechanical Ventilation: Scoping Review

Homira Osman, Refika Hamutcu Ersu, Marta Kamińska, The Thanh Diem Nguyen et al.
ERJ Open Research
Respiratory Support and Mechanisms
article

Outcomes in Studies for Individuals Receiving Home Mechanical Ventilation: Scoping Review

Homira Osman, Refika Hamutcu Ersu, Marta Kamińska, The Thanh Diem Nguyen, Jean‐Paul Praud, Tareq Alabdoulsalam, Alba Torrent‐Vernetta, Nisha Cithiravel, Sherri Lynne Katz, Indra Narang, David Zielinski, Colleen M. O’Connell, Tetyana Kendzerska, Mika Laura Nonoyama, Marielena Dibartolo, David Wensley, Douglas A. Mckim, Kevan Mehta, Jackie Chiang, Marie Wright, David J. Leasa, Jalal Moolji, Reshma Amin, Lisa F. Wolfe, Lena Xiao, Anu Tandon, Samantha Mekhuri, Munazzah Ambreen, Joseph S. Munn, Joanna E. MacLean, David John Berlowitz, Mathew M. Cherian, Louise Rose, Jessie Cunningham, Thilipan Thaventhiran, Aditi Shah, Irvin Mayers, Laura Istanboulian, Francine Buchanan, Kevin Solverson, Veronique Adam, María Codesal, Haley Fishman, Andrea H. S. Loewen, Robert G. Varadi, Audrey Lim, Regina Pizzuti, Eleni Giannouli, Cheryl R. Laratta, Craig Dale, Andrea S. Gershon, Kasthuri Satgunanathan, Tuyen Tran, Tim Ramsay, Faiza Syed, Ron Butler, Danielle Adam, Susi Vander Wyk, Florence Birru, Jenny Shi, Kali Barrett, Jody Platt, Dimas Mateos, Dean Hummel, Lily Johnson, Sujay Mondal, Aaron St. Laurent
article en

Abstract

Background Home mechanical ventilation (HMV) is a life-sustaining therapy for individuals with chronic respiratory failure. Despite a high morbidity and mortality of patients using HMV, few clinical trials inform practice. HMV-related research is impacted by the absence of a core outcome set (COS). This scoping review informs the development of a COS to be reported in interventional studies for individuals requiring HMV. Methods We conducted a scoping review including interventional and cohort studies recruiting adults and children receiving HMV. We searched six databases in March 2026, and conducted citation tracking of relevant studies. Study screening and data extraction were conducted independently in duplicate. We categorised outcomes using the Core Outcome Measures in Effectiveness Trials (COMET) 38-domain taxonomy, and assessed reporting quality using established criteria. Results Of 21 467 records screened, 287 studies were included: 78% adult, 18% paediatric, and 4% mixed populations. Studies evaluated HMV initiation (56%), patient interventions (31%), caregiver interventions (11%); or a combination of components (2%). We identified 71 distinct primary and 100 distinct secondary outcomes representing all COMET core areas. Primary outcomes were frequently in the respiratory, hospital, and mortality/survival domains, while respiratory, delivery of care, and global quality of life outcomes were predominant among secondary outcomes. Outcome reporting quality was high in 68% of studies. Conclusion Outcome selection in HMV studies is highly variable, supporting the need for a COS to improve consistency of future research informing clinical decision-making and policy.

ERJ Open Research
Northwestern University (US), Alberta Health Services (CA), Dalhousie University (CA), Sunnybrook Health Science Centre (CA), Université de Sherbrooke (CA), University of British Columbia (CA), Imperial College Healthcare NHS Trust (GB), University of Alberta (CA), University of Calgary (CA), King's College London (GB), University of Toronto (CA), Children's Hospital of Eastern Ontario (CA), Muscular Dystrophy Canada (CA), Izaak Walton Killam Health Centre (CA), Ottawa Hospital (CA), London Health Sciences Centre (CA), Hospital for Sick Children (CA), McGill University Health Centre (CA), McMaster Children's Hospital (CA), Alberta Children's Hospital (CA), Centre Hospitalier Universitaire Sainte-Justine (CA), University of Alberta Hospital (CA), South London Healthcare NHS Trust (GB), Institute for Breathing and Sleep (AU), West Park Healthcare Centre (CA), Vall d'Hebron Hospital Universitari (ES), BC Children's Hospital (CA), Austin Health (AU), Ottawa Hospital Research Institute (CA), Sickkids Research Institute (CA), University of Manitoba (CA), McGill University (CA), Hamilton Health Sciences (CA), McMaster University (CA)
Good health and well-being
Openalex Percentile: Top 12%
Respiratory Support and Mechanisms
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