Environmental Estrogen Disruption, Lamellar-Body Dysfunction, and Malassezia: A Testable Skin-Barrier Hypothesis

This research hypothesis proposes that environmental estrogenic disruption may impair epidermal lamellar-body function and lipid-barrier integrity, potentially altering host–Malassezia interactions. It integrates existing literature into a testable model and outlines experiments that could support or refute the proposed pathway.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-29
DOI
https://doi.org/10.5281/zenodo.23776407
Primary Topic
Nail Diseases and Treatments
Type
preprint
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preprint

Environmental Estrogen Disruption, Lamellar-Body Dysfunction, and Malassezia: A Testable Skin-Barrier Hypothesis

Sensory Solutions Lab, Jessicka Knight
2 links
Zenodo (CERN European Organization for Nuclear Research)
Nail Diseases and Treatments
preprint

Environmental Estrogen Disruption, Lamellar-Body Dysfunction, and Malassezia: A Testable Skin-Barrier Hypothesis

Sensory Solutions Lab, Jessicka Knight
preprint en

Abstract

This research hypothesis proposes that environmental estrogenic disruption may impair epidermal lamellar-body function and lipid-barrier integrity, potentially altering host–Malassezia interactions. It integrates existing literature into a testable model and outlines experiments that could support or refute the proposed pathway.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Nail Diseases and Treatments
DOIOpen Access PDFOpenAlex
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Environmental Estrogen Disruption, Lamellar-Body Dysfunction, and Malassezia: A Testable Skin-Barrier Hypothesis — Sensory Solutions Lab, Jessicka Knight · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS