HUBUNGAN ANTARA KADAR ASAM URAT DENGAN KADAR hs-CRP PADA PASIEN PROLANIS HIPERTENSI

Hypertension is a chronic disease that may increase the risk of cardiovascular disease. Elevated uric acid levels are known to contribute to oxidative stress and inflammatory processes, while high-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker used to assess cardiovascular disease risk. This study aimed to determine the relationship between uric acid and hs-CRP levels among hypertensive Prolanis patients at Farmalab Medical Laboratory, Bangkalan Regency. This study employed a quantitative observational analytic design with a cross-sectional approach. Serum samples were obtained from 30 hypertensive Prolanis patients. Uric acid levels were measured using an Homogenus Enzymatic Colometric method, while hs-CRP levels were measured using Fluorescence Immunoassay (FIA). Data were analyzed using the Shapiro-Wilk test and Spearman correlation. The mean uric acid level was 5.913 mg/dL and the mean hs-CRP level was 2.560 mg/L. Spearman correlation analysis showed no significant relationship between uric acid and hs-CRP levels (r = -0.218; p = 0.246). The correlation coefficient indicated a very weak negative relationship. In conclusion, uric acid levels were not significantly associated with hs-CRP levels among hypertensive Prolanis patients. ABSTRAK Hipertensi merupakan penyakit kronis yang berkaitan dengan peningkatan risiko penyakit kardiovaskular dan melibatkan proses inflamasi serta gangguan metabolik. Kadar asam urat yang meningkat diduga berkaitan dengan inflamasi sistemik, yang dapat dinilai melalui pemeriksaan high-sensitivity C-reactive protein (hs-CRP). Penelitian ini bertujuan untuk mengetahui hubungan antara kadar asam urat dan hs-CRP pada pasien Program Pengelolaan Penyakit Kronis (PROLANIS) hipertensi di Laboratorium Medis Farmalab, Kabupaten Bangkalan. Penelitian ini menggunakan desain kuantitatif analitik observasional dengan pendekatan cross-sectional. Sampel penelitian terdiri atas 30 pasien perempuan berusia 40–65 tahun yang dipilih menggunakan teknik purposive sampling. Pemeriksaan asam urat menggunakan metode homogeneous enzymatic colorimetric, sedangkan hs-CRP menggunakan metode fluorescence immunoassay (FIA). Analisis data dilakukan menggunakan uji normalitas Shapiro–Wilk dan korelasi Spearman. Hasil penelitian menunjukkan rata-rata kadar asam urat sebesar 5,913 mg/dL dan hs-CRP sebesar 2,560 mg/L. Uji korelasi Spearman menunjukkan koefisien korelasi sebesar −0,218 dengan nilai p = 0,246. Dengan demikian, tidak terdapat hubungan yang signifikan antara kadar asam urat dan hs-CRP pada pasien PROLANIS hipertensi.