Sense-and-respond: Engineered bacteria drive epithelial repair during gut inflammation
Zhao et al. 1 1. Zhao, Y. ∙ Sun, Y. ∙ Zhu, X. ... An engineered probiotic for diagnosis and mucosal healing in inflammatory bowel disease Cell Rep. 2026; 45 :118171 Full Text Full Text (PDF) Scopus (0) PubMed Google Scholar engineer a reactive oxygen species-responsive probiotic strain of Escherichia coli that senses intestinal inflammation and responds by locally delivering IL-22-Fc to promote epithelial repair, establishing an integrated sense-and-respond platform for inflammatory bowel disease diagnosis and mucosal healing.
Authors
- Sushrut Jangi (ORCID: https://orcid.org/0000-0001-5488-5770)
- Cammie F. Lesser (ORCID: https://orcid.org/0000-0002-1702-6333)
- Stevens E. Robertin
Institutions
- Tufts University (US)
- Tufts Medical Center (US)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1016/j.celrep.2026.118198
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00