Trastuzumab emtansine silences Cyp2B6.

Mechanism of action for antibody drug conjugates has not yet been completely elucidated. We demonstrate here through the use of RNA-sequencing specific silencing of Cyp2B6 by trastuzumab emtansine, T-DM1.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-29
DOI
https://doi.org/10.5281/zenodo.23771757
Primary Topic
HER2/EGFR in Cancer Research
Type
preprint
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preprint

Trastuzumab emtansine silences Cyp2B6.

Shahan Mamoor
5 links
Zenodo (CERN European Organization for Nuclear Research)
HER2/EGFR in Cancer Research
preprint

Trastuzumab emtansine silences Cyp2B6.

Shahan Mamoor
preprint en

Abstract

Mechanism of action for antibody drug conjugates has not yet been completely elucidated. We demonstrate here through the use of RNA-sequencing specific silencing of Cyp2B6 by trastuzumab emtansine, T-DM1.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
HER2/EGFR in Cancer Research
DOIOpen Access PDFOpenAlex
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Trastuzumab emtansine silences Cyp2B6. — Shahan Mamoor · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS