FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF DOMPERIDONE LOADED NANOSTRUCTURED LIPID CARRIERS BY QbD

ABSTRACTDomperidone is a prokinetic and antiemetic medication. It is a member of the class of medicationsknown as dopamine antagonists. Stearic acid and oleic acid were utilized as liquid and solid lipids inthe high-pressure homogenization method to produce dopamine-loaded nanostructured lipid carriers(NLCs). Fourier transform infrared spectroscopy, or FTIR, was used to characterize the generatedNLCs. It was discovered that the encapsulation efficiency ranged from 64 to 86%. According toNLC's in-vitro release profile, every batch was evident. continuous medication release for a fulltwelve hours. Based on the medication release characteristics in vitro The NLCs' spherical shape andsmooth surface were demonstrated by visualization experiments, and it was also observed that thedrug release from NLCs rose with the solid-lipid ratio. Among F9 is the formulation with the highestdrug release out of the nine. Based on the data collected for this study, it appears that dopamine maybe delivered by nanostructured lipid carriers, which may decrease the frequency of doses. Dependentvariables, including zeta potential, particle size, and in-vitro drug release, were measured usingDesign Export 13 software and 32 factorial design Central composite design with Response surfaceapproach. Preliminary data showed that increasing the stabilizer concentration and sonication cyclesled to a decrease in zeta potential (-14.0) and particle size (243 nm) and an increase in drug release(96.33±0.02).