Evidence for the Existence of Neural Stem‐Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia

Cardiac function is modulated by the intrinsic cardiac nervous system (ICNS), which integrates autonomic signals and undergoes remodeling in pathological conditions. Here, we demonstrate that adult rodent ICNS ganglia harbor neural stem-like cells that proliferate in vitro, form neurospheres, self-renew, and generate neurons expressing βIII-tubulin and PGP 9.5. In vivo, cells expressing the stem cell marker SOX2 are detected within ICNS ganglia. Moreover, cardiac injury induced by monocrotaline increases the number of SOX2-positive cells expressing the cell cycle marker Ki67 and the number of EdU-incorporating, nestin-expressing cells within the ICNS. Together, our data provide the first evidence of neural stem-like cells in adult ICNS ganglia and suggest their potential role in cardiac neuroplasticity.

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Publication Details

Journal
The FASEB Journal
Published
2026-10-29
DOI
https://doi.org/10.1096/fj.202601054r
Primary Topic
Neurogenesis and neuroplasticity mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Evidence for the Existence of Neural Stem‐Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia

Patrick Bois, Michela Crotti, Laëtitia Cousin, Valérie Coronas et al.
1 links
The FASEB Journal
Neurogenesis and neuroplasticity mechanisms
article

Evidence for the Existence of Neural Stem‐Like Cells in Adult Rodent Intrinsic Cardiac Nervous Ganglia

Patrick Bois, Michela Crotti, Laëtitia Cousin, Valérie Coronas, Patricia Arnault, Jocelyn Bescond, Guénaëlle Lizot, Aurélien Chatelier, Fabrice Antigny, Alice Jean, Bruno Constantin, Mathieu Gourmelon
article en

Abstract

Cardiac function is modulated by the intrinsic cardiac nervous system (ICNS), which integrates autonomic signals and undergoes remodeling in pathological conditions. Here, we demonstrate that adult rodent ICNS ganglia harbor neural stem-like cells that proliferate in vitro, form neurospheres, self-renew, and generate neurons expressing βIII-tubulin and PGP 9.5. In vivo, cells expressing the stem cell marker SOX2 are detected within ICNS ganglia. Moreover, cardiac injury induced by monocrotaline increases the number of SOX2-positive cells expressing the cell cycle marker Ki67 and the number of EdU-incorporating, nestin-expressing cells within the ICNS. Together, our data provide the first evidence of neural stem-like cells in adult ICNS ganglia and suggest their potential role in cardiac neuroplasticity.

The FASEB JournalVol. 40(21)
Inserm (FR), Université Paris-Saclay (FR), Université de Poitiers (FR), Assistance Publique – Hôpitaux de Paris (FR), Hypertension pulmonaire : physiopathologie et innovation thérapeutique (FR), Hôpital Marie Lannelongue (FR), Hôpital Paris Saint-Joseph (FR), Bicêtre Hospital (FR), Université Laval (CA), Canaux et Connexines dans les Cancers et Cellules Souches (FR), Physiopathologie et Régulation des Transports Ioniques (FR), Centre de recherche CERVO (CA)
Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Ligue Contre le Cancer
Good health and well-being
Openalex Percentile: Top 15%
Neurogenesis and neuroplasticity mechanisms
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