Posterior Segment Herpes Simplex Virus-2 Ocular Disease in Children
Five pediatric patients not known to be immunocompromised developed severe posterior segment herpes simplex virus-2 ocular disease at a median age of 13 years. Presentations mimicked noninfectious uveitis, optic neuritis, vasculitis and necrotizing retinitis, often delaying diagnosis. Intraocular polymerase chain reaction confirmed herpes simplex virus-2 in 4. Visual morbidity, retinal detachment and the requirement for surgical intervention were common, supporting early polymerase chain reaction testing, antiviral therapy and surveillance.
Authors
- Geraldine Huynh (ORCID: https://orcid.org/0000-0001-6785-2871)
- Peter J. Kertes (ORCID: https://orcid.org/0000-0002-0348-5096)
- Rebecca Pellett Madan (ORCID: https://orcid.org/0000-0002-7968-8287)
- Joan L. Robinson (ORCID: https://orcid.org/0000-0001-9831-5681)
- Catherine Burton (ORCID: https://orcid.org/0000-0002-8361-5582)
- Federico R. Laham
- David Winston Kimberlin (ORCID: https://orcid.org/0000-0001-9038-9109)
- MATTHEW T. S. TENNANT (ORCID: https://orcid.org/0000-0001-8810-4821)
- Upton Allen (ORCID: https://orcid.org/0000-0002-2326-7731)
Institutions
- Orlando Health (US)
- University of Alberta (CA)
- University of Toronto (CA)
- Arnold Palmer Hospital for Children (US)
- University of Alabama at Birmingham (US)
- New York University (US)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1097/inf.0000000000005461
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00