The complexity of cerebral small vessel disease: In search of the ideal mouse model

Currently, there are few animal models that reflect the physiological complexity of cerebral small vessel disease. Ruan et al. 1 1. Ruan, J. ∙ Nasrollahi, A. ∙ Martin, C. ... Loss of laminin-γ1 in pericytes impairs microvascular function and cognition Cell Rep. 2026; 45 , 117904 Full Text Full Text (PDF) Scopus (1) Google Scholar presented a pericyte-specific knockout of laminin-γ1 that exhibited several key disease-typical characteristic features at 11 months of age.

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Journal
Cell Reports
Published
2026-10-29
DOI
https://doi.org/10.1016/j.celrep.2026.118164
Primary Topic
Cerebrovascular and genetic disorders
Type
article
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article

The complexity of cerebral small vessel disease: In search of the ideal mouse model

Małgorzata Burek
1 links
Cell Reports
Cerebrovascular and genetic disorders
article

The complexity of cerebral small vessel disease: In search of the ideal mouse model

Małgorzata Burek
article en

Abstract

Currently, there are few animal models that reflect the physiological complexity of cerebral small vessel disease. Ruan et al. 1 1. Ruan, J. ∙ Nasrollahi, A. ∙ Martin, C. ... Loss of laminin-γ1 in pericytes impairs microvascular function and cognition Cell Rep. 2026; 45 , 117904 Full Text Full Text (PDF) Scopus (1) Google Scholar presented a pericyte-specific knockout of laminin-γ1 that exhibited several key disease-typical characteristic features at 11 months of age.

Cell ReportsVol. 45(11)
Universitätsklinikum Würzburg (DE)
Good health and well-being
Openalex Percentile: Top 14%
Cerebrovascular and genetic disorders
DOIOpen Access PDFOpenAlex
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The complexity of cerebral small vessel disease: In search of the ideal mouse model — Małgorzata Burek · Cell Reports (2026) | TGRS Research Map | TGRS