Intramolecular O−H···O Hydrogen Bonding in Crystal Structures of Ortho -Hydroxymethyl-hydroxy (Hetero)arenes
Abstract A crystallographic study of pyridoxine salts, combined with a survey of ortho-hydroxymethyl-hydroxy arenes and heteroarenes in the Cambridge Structural Database, was used to evaluate the persistence of intramolecular hydrogen bonding in crystalline ortho-hydroxymethyl-hydroxy (hetero)arenes. The presented analyses suggest that steric effects play a significant role in the formation of intramolecular hydrogen bonds in this class of compounds.
Authors
- Monika Stojanovska Pecova (ORCID: https://orcid.org/0000-0002-5698-1624)
- Valerio Bertolasi (ORCID: https://orcid.org/0000-0002-7572-3532)
- Dejan-Krešimir Buč̌ar (ORCID: https://orcid.org/0000-0001-6393-276X)
- Catherine Tuleu (ORCID: https://orcid.org/0000-0001-8384-357X)
- Aleksandar Cvetkovski (ORCID: https://orcid.org/0000-0002-8827-0245)
- Dritan Hasa (ORCID: https://orcid.org/0000-0003-2147-9121)
- Nenad Judaš (ORCID: https://orcid.org/0000-0002-8084-6748)
- Petre Makreski (ORCID: https://orcid.org/0000-0003-0662-5995)
- V. Ferretti (ORCID: https://orcid.org/0000-0001-5515-9615)
- Diba Keyhanfar
Institutions
- University of Trieste (IT)
- University of Zagreb (HR)
- University of Ferrara (IT)
- Goce Delcev University (MK)
- University College London (GB)
- Ss. Cyril and Methodius University in Skopje (MK)
Publication Details
- Journal
- Crystal Growth & Design
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1021/acs.cgd.6c00350
- Primary Topic
- Crystallography and molecular interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Engineering and Physical Sciences Research Council