Okgyeamides A–C: Cyclic Pentapeptides with Distinct Tyr–Trp C–C and C–N Cross-Links from a Cave-Derived Streptomyces sp.
Abstract Okgyeamides A–C (1–3), cyclic pentapeptides with a YPWIP sequence and distinct Tyr–Trp C–C and C–N cross-links, were isolated from cave-derived Streptomyces sp. SOG2–3 KCTC19252P. Their structures were characterized by NMR, HRESIMS, advanced Marfey’s and GITC analyses, DP4+ calculations, and ECD analysis. Genome analysis identified a candidate precursor–P450 locus, okgA–okgB, consistent with a ribosomal origin. Okgyeamide A (1) showed ABTS radical-scavenging activity under the conditions tested.
Authors
- Yeon Hee Ban (ORCID: https://orcid.org/0000-0002-6343-8603)
- 박신애
- Ran Hui Kim
- Munhyung Bae (ORCID: https://orcid.org/0000-0002-7771-7320)
- Yong-Joon Cho
- Sunhee Park
Institutions
- Gachon University (KR)
- Kangwon National University (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-10-28
- DOI
- https://doi.org/10.1021/acs.orglett.6c04374
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Basic Science Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea