Advanced liver fibrosis is independently associated with diabetic peripheral neuropathy in type 2 diabetes
BACKGROUNDMetabolic dysfunction-associated steatotic liver disease (MASLD) frequently coexists with type 2 diabetes mellitus (T2DM), but it remains unclear whether MASLD-related liver fibrosis independently drives diabetic peripheral neuropathy (DPN) and its specific clinical subtypes. AIMTo evaluate the independent association between MASLD-related liver fibrosis and the overall risk of DPN and its specific subtypes in individuals with T2DM.advanced fibrosis (stage ≥ 3) was associated with significantly higher DPN and DSPN prevalence.Following multivariable adjustment, advanced histological fibrosis conferred an elevated risk of DPN (OR: 4.67, 95%CI: 1.33-16.38)and DSPN (OR: 13.01, 95%CI: 1.40-121.41). CONCLUSIONLiver fibrosis is independently associated with an increased risk of DPN, specifically the DSPN subtype.Clinical surveillance for neuropathy should be intensified in T2DM patients who present with advanced liver fibrosis.
Authors
- Hongmei Yan (ORCID: https://orcid.org/0000-0002-9629-1396)
- Xiaopeng Zhu (ORCID: https://orcid.org/0000-0001-8830-4954)
- Jihong Dong (ORCID: https://orcid.org/0000-0002-3718-3328)
- Xinxia Chang
- Miao Zhang
- Ming-Feng Xia
- Yu-Ying Zhang
- Chen-Min Fan
- Xin-Yu Yang
- Hua Bian
- Bing-Er Xu
- Shu-Qi Li
- Xin Gao
- Xiao-Yang Sun
- Qi-Ling Liu
Institutions
- Fudan University (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2026-10-28
- DOI
- https://doi.org/10.4239/wjd.125253
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Fudan University
- Science and Technology Commission of Shanghai Municipality
- National Science and Technology Major Project