The Hygieia Platform: Autonomous In Silico Systems Pharmacology, Multi-Carrier Delivery Matrices and Deterministic Combinatorial Lead Optimization Platform
This whitepaper outlines The Hygieia Platform, an in silico systems pharmacology and combinatorial formulation discovery engine. Combining 6-compartment Physiologically-Based Pharmacokinetic (PBPK) differential modeling, Quantitative Systems Pharmacology (QSP) receptor dynamics, and Chou-Talalay drug synergy algorithms, Hygieia accelerates multi-carrier botanical delivery optimization with strict ASME V&V 40 verification. Report identifier: HYG-TR-2026-V2.1Official portal: https://sampoaios.com
Authors
- Harri Lanzett (ORCID: https://orcid.org/0000-0002-9574-3805)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-10-28
- DOI
- https://doi.org/10.5281/zenodo.23739601
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00