Traveling waves in a tumor invasion model with chemotaxis and haptotaxis effects

This paper investigates the existence and asymptotic properties of traveling wave solutions for a cross-diffusion tumor invasion model incorporating chemotaxis, haptotaxis, and logistic tumor growth. We establish the existence of smooth traveling waves connecting biologically relevant equilibria for chemotactic sensitivities $ \chi \le \chi^*(\xi, \mu, A) $ and wave speeds $ c \ge c^*(\chi, \xi, \mu, A) $. Notably, when $ \xi $ is sufficiently small and chemotaxis vanishes ($ \chi \to 0 $), the speed threshold $ c^* $ approaches the classical Fisher-KPP critical speed $ 2\sqrt{\mu} $. Furthermore, we derive the optimal exponential decay rates of the wave profiles near both equilibrium states, providing a precise description of the invasion front's shape. A central result of this work is the demonstration that logistic growth is indispensable: we prove that in its absence, no smooth, non-negative traveling wave exists, highlighting the essential role of tumor cell proliferation in supporting invasive fronts. The analysis overcomes the mathematical challenges arising from the strongly coupled, non-quasimonotone structure of the system through a layered decoupling strategy, parabolic regularization, and a fixed-point argument.

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Publication Details

Journal
Discrete and Continuous Dynamical Systems - B
Published
2026-10-28
DOI
https://doi.org/10.3934/dcdsb.2026.104227
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
0.00

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article

Traveling waves in a tumor invasion model with chemotaxis and haptotaxis effects

Yinxin Cheng, Jingxue Yin, Chunhua Jin
1 links
Discrete and Continuous Dynamical Systems - B
Mathematical Biology Tumor Growth
article

Traveling waves in a tumor invasion model with chemotaxis and haptotaxis effects

Yinxin Cheng, Jingxue Yin, Chunhua Jin
article en

Abstract

This paper investigates the existence and asymptotic properties of traveling wave solutions for a cross-diffusion tumor invasion model incorporating chemotaxis, haptotaxis, and logistic tumor growth. We establish the existence of smooth traveling waves connecting biologically relevant equilibria for chemotactic sensitivities $ \chi \le \chi^*(\xi, \mu, A) $ and wave speeds $ c \ge c^*(\chi, \xi, \mu, A) $. Notably, when $ \xi $ is sufficiently small and chemotaxis vanishes ($ \chi \to 0 $), the speed threshold $ c^* $ approaches the classical Fisher-KPP critical speed $ 2\sqrt{\mu} $. Furthermore, we derive the optimal exponential decay rates of the wave profiles near both equilibrium states, providing a precise description of the invasion front's shape. A central result of this work is the demonstration that logistic growth is indispensable: we prove that in its absence, no smooth, non-negative traveling wave exists, highlighting the essential role of tumor cell proliferation in supporting invasive fronts. The analysis overcomes the mathematical challenges arising from the strongly coupled, non-quasimonotone structure of the system through a layered decoupling strategy, parabolic regularization, and a fixed-point argument.

Discrete and Continuous Dynamical Systems - BVol. 43(0)
South China Normal University (CN)
National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province
Openalex Percentile: Top 13%
Mathematical Biology Tumor Growth
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