Synthesis and Biological Activity of Iminophosphine Copper(I) Complexes Derived from 2-(Diphenylphosphino)benzaldehyde and 4-Substituted-Benzylamines
Abstract A panel of copper(I) complexes was isolated by metal-templated reactions starting from 2-(diphenylphosphino)benzaldehyde and some 4-substituted-benzylamines, and by changing the ratio between metal and ligand and the anion. The spectroscopic characterization of the copper(I) complexes was completed by discussion of some structures obtained by single-crystal X-ray diffraction. The copper(I) complexes were assayed in vitro against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. Cell viability was assessed both in nonmalignant and malignant cell lines, namely Vero and Caco-2 cells, respectively. While the tested compounds show only a nonspecific antibacterial effect against S. aureus, some of them showed an interesting antiproliferative activity.
Authors
- Giorgio Pelosi (ORCID: https://orcid.org/0000-0002-7946-0602)
- Matteo Incerti (ORCID: https://orcid.org/0000-0003-0687-8765)
- Francesca Bonvicini (ORCID: https://orcid.org/0000-0001-8101-9835)
- Dominga Rogolino (ORCID: https://orcid.org/0000-0003-2295-5783)
- Luca Rigamonti (ORCID: https://orcid.org/0000-0002-9875-9765)
- Diego Montagner (ORCID: https://orcid.org/0000-0002-1034-9623)
- Mauro Carcelli (ORCID: https://orcid.org/0000-0001-5888-4556)
- Lorenzo Verderi (ORCID: https://orcid.org/0009-0001-1316-4579)
- Alessio Zavaroni (ORCID: https://orcid.org/0000-0002-9761-7247)
- Lisa Menegaldo
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Parma (IT)
- National University of Ireland, Maynooth (IE)
- University of Bologna (IT)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-10-28
- DOI
- https://doi.org/10.1021/acsomega.6c08107
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dipartimenti di Eccellenza
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Parma