Relapse test: Droplet Digital PCR vs Hybrid-Capture NGS at 0.01% VAF — triplicate runs to hold 95% specificity

Compare Droplet Digital PCR and hybrid-capture NGS for ctDNA MRD at 0.01% VAF, and learn why triplicate runs are needed to hold 95% specificity. Independent technical note mirroring the canonical version: https://quantbio.me/blog/relapse-test-droplet-digital-pcr-vs-hybrid-capture-ngs-at-001-vaf-triplicate-runs-to-hold-95-specificity.php Sources consulted: https://www.bluusun.com/

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-28
DOI
https://doi.org/10.5281/zenodo.23724640
Primary Topic
Cancer Genomics and Diagnostics
Type
preprint
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preprint

Relapse test: Droplet Digital PCR vs Hybrid-Capture NGS at 0.01% VAF — triplicate runs to hold 95% specificity

Dr. Leah Fontaine
4 links
Zenodo (CERN European Organization for Nuclear Research)
Cancer Genomics and Diagnostics
preprint

Relapse test: Droplet Digital PCR vs Hybrid-Capture NGS at 0.01% VAF — triplicate runs to hold 95% specificity

Dr. Leah Fontaine
preprint en

Abstract

Compare Droplet Digital PCR and hybrid-capture NGS for ctDNA MRD at 0.01% VAF, and learn why triplicate runs are needed to hold 95% specificity. Independent technical note mirroring the canonical version: https://quantbio.me/blog/relapse-test-droplet-digital-pcr-vs-hybrid-capture-ngs-at-001-vaf-triplicate-runs-to-hold-95-specificity.php Sources consulted: https://www.bluusun.com/

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Cancer Genomics and Diagnostics
DOIOpen Access PDFOpenAlex
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Relapse test: Droplet Digital PCR vs Hybrid-Capture NGS at 0.01% VAF — triplicate runs to hold 95% specificity — Dr. Leah Fontaine · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS