Evaluation of the effectiveness of the combined influence of ovomin and antibacterial therapy

Sixty-nine postpartum women with postpartum uterine inflammation (mean age 25.8 ± 2.2 years) were examined in the postpartum department of the 3rd Minsk City Clinical Hospital named after E. V. Klumov. The control group consisted of 19 postpartum women with a normal postpartum period (mean age 24.4 ± 2.6 years).The study group included 34 patients who received drug therapy according to the treatment protocol in combination with a course of ovomin (1 ml of a solution containing 12,000 ATE, diluted in 250 ml of saline), administered intravenously by drip once daily for 7 days. The comparison group consisted of 35 women in labor who received drug treatment according to the protocol (intravenous drip infusion of 100 ml of 0.5 % metronidazole solution 3 times a day and 2 g of ciprofloxacin 400 mg once a day) for 7 days. All patients underwent uterotonic therapy. It was found that the inclusion of ovomine in the complex therapy of uterine inflammation contributes to an increase in its effectiveness, which is characterized by the normalization of clinical and laboratory parameters and a decrease in the severity of clinical symptoms of the disease from 52.7 ± 10.05 to 10.3 ± 2.65 points (p = 0.029), which was significantly different from the corresponding value after treatment in the comparison group, which was 19.0points (p = 0.011). The treatment effect per woman in labor after complex treatment was 1.25 times higher than the effectiveness of conventional therapy (p = 0.012). Intravenous drip administration of 1 ml of ovomin, a solution containing 12,000 ATE and diluted in 250 ml of saline, once daily for 7 days has a pronounced anti-inflammatory and anti-lysosomal effect, as evidenced by a direct correlation between uterine tone (based on cavity size) and CRP levels (r = 0.086, p = 0.0001), as well as serum cathepsin expression (r = 0.68, p = 0.021), reflecting the high effectiveness of ovomin in the complex treatment of patients with inflammatory uterine diseases.