Direct C–H Phosphorothiolation of Indoles under Visible-Light Irradiation
Abstract We report a photocatalyst-free, visible-light-driven cross-dehydrogenative coupling protocol for the direct C3-phosphorothiolation of indoles, using inexpensive KI as catalyst and atmospheric oxygen as oxidant. This transition-metal-free method avoids the use of hazardous peroxides and malodorous thiols, enabling the utilization of odorless O,O-diethyl S-hydrogen phosphorothioate and unfunctionalized indoles with good practicability. The obtained phosphorothiolated indoles are readily converted to diverse dithio-functionalized compounds. This operationally simple, sustainable method provides a practical platform for green C–H phosphorothiolation.
Authors
- Anaerguli Wufuer
- Guo Tang (ORCID: https://orcid.org/0000-0002-4349-398X)
- Chenjiang Liu (ORCID: https://orcid.org/0000-0002-8241-0809)
- Ziren Chen (ORCID: https://orcid.org/0000-0002-3298-9584)
- Bin Wang (ORCID: https://orcid.org/0000-0002-8755-6401)
- Yonghong Zhang (ORCID: https://orcid.org/0000-0002-7740-9408)
- Yu Xia (ORCID: https://orcid.org/0000-0002-0591-9169)
- Zainure Osman
- Shaofeng Wu
- He Chen
- Jiameng Guo
Institutions
- Xinjiang Normal University (CN)
- Xiamen University (CN)
- Xinjiang University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-10-28
- DOI
- https://doi.org/10.1021/acs.orglett.6c04311
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Xinjiang Province
- National Natural Science Foundation of China