Alzheimer’s disease research must connect vascular molecular phenotypes with physiology
Molecular profiling studies have mapped vascular alterations in Alzheimer's disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion.
Authors
- Jonas J. Neher (ORCID: https://orcid.org/0000-0003-1346-8924)
- Jessica S. Wagner (ORCID: https://orcid.org/0009-0004-8585-6998)
- Thomas S. Lewis
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Munich Cluster for Systems Neurology (DE)
- German Center for Neurodegenerative Diseases (DZNE) Dresden (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- PLoS Biology
- Published
- 2026-10-28
- DOI
- https://doi.org/10.1371/journal.pbio.3004051
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft