Antioxidant Interventions in Inherited Ataxias: A Review of Neurological Outcomes and Disease Progression

This literature review examines whether antioxidant interventions, including coenzyme Q10 (CoQ10), idebenone, and vitamin E, improve neurological function or slow disease progression in inherited ataxias, particularly Friedreich ataxia and spinocerebellar ataxias. It explores the role of oxidative stress and mitochondrial dysfunction and compares findings from human studies using clinical measures such as SARA and ICARS. The paper considers whether biological improvements translate into meaningful benefits for patients and identifies gaps in the existing evidence.