Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry

Background/Objectives: To determine the proportion of elderly-onset sarcoidosis (EOS) and to assess the influence of age at diagnosis on pulmonary and extrapulmonary manifestations. Methods: Retrospective multicentre study using the Spanish SARCOGEAS registry, including adults with sarcoidosis diagnosed across 36 hospitals. EOS was defined as diagnosis at ≥65 years. Associations between clinical features and age were assessed using multivariable logistic and linear regression models, including sex-stratified analyses. Results: Among 2187 patients (mean age 48.6 ± 15.2 years, 61.36% women), 358 (16.37%) had EOS. In multivariable analyses, female sex (OR 1.86; β +5.02 years), White ethnicity (OR 5.43; β +4.85 years), and renal involvement (OR 2.29; β +6.86 years) were independently associated with EOS and older age at diagnosis, whereas cutaneous (OR 0.49; β −3.50 years), articular or bone (OR 0.37; β −3.10 years), and neurological involvement (OR 0.49; β −2.47 years) were associated with non-EOS and younger age at diagnosis. Exploratory sex-stratified analyses suggested additional patterns: in women, calcium metabolism abnormalities were associated with EOS (OR 1.74) and older age at diagnosis (β +4.91 years), and ear–nose–throat involvement was associated with older age at diagnosis (β +5.74 years). Regarding pulmonary involvement, CT-based Scadding stage II was associated with younger age at diagnosis (β −3.75 years) in women and CT-based Scadding stage IV with older age at diagnosis (β +6.57 years) in men. Conclusions: EOS accounted for 16.37% of sarcoidosis cases. Older age at diagnosis was associated with specific patterns of organ involvement, which changed gradually across the age spectrum, some of them differing by sex in exploratory analyses. Further studies are needed to confirm these findings.

Authors

Institutions

Publication Details

Journal
Journal of Clinical Medicine
Published
2026-10-27
DOI
https://doi.org/10.3390/jcm15218355
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry

Begoña de Escalante Yangüela, Mariona Bonet, Carlos Feijoo-Massó, Alejandra Flores-Chávez et al.
2 links
Journal of Clinical Medicine
Sarcoidosis and Beryllium Toxicity Research
article

Elderly-Onset Sarcoidosis and the Influence of Age on Clinical Phenotypes: A Multicentre Analysis from the SARCOGEAS Registry

Begoña de Escalante Yangüela, Mariona Bonet, Carlos Feijoo-Massó, Alejandra Flores-Chávez, Antonio Javier Chamorro Fernández, María García-González, Miriam Akasbi, Ana Noblejas Mozo, Manuel Ramos‐Casals, Guillem Policarpo Torres, A. Alguacil, Andrés González García, Borja de Miguel-Campo, Pilar Brito‐Zerón, Eva Fonseca Aizpuru, Rosana Rouco, Miguel López-Dupla, Álex Mayer-Fuentes, Ricardo Gómez de la Torre, María Barrientos, Maria Gracia Cruz Caparrós, Cristina Soler-I-Ferrer, Salvador García Morillo
article en

Abstract

Background/Objectives: To determine the proportion of elderly-onset sarcoidosis (EOS) and to assess the influence of age at diagnosis on pulmonary and extrapulmonary manifestations. Methods: Retrospective multicentre study using the Spanish SARCOGEAS registry, including adults with sarcoidosis diagnosed across 36 hospitals. EOS was defined as diagnosis at ≥65 years. Associations between clinical features and age were assessed using multivariable logistic and linear regression models, including sex-stratified analyses. Results: Among 2187 patients (mean age 48.6 ± 15.2 years, 61.36% women), 358 (16.37%) had EOS. In multivariable analyses, female sex (OR 1.86; β +5.02 years), White ethnicity (OR 5.43; β +4.85 years), and renal involvement (OR 2.29; β +6.86 years) were independently associated with EOS and older age at diagnosis, whereas cutaneous (OR 0.49; β −3.50 years), articular or bone (OR 0.37; β −3.10 years), and neurological involvement (OR 0.49; β −2.47 years) were associated with non-EOS and younger age at diagnosis. Exploratory sex-stratified analyses suggested additional patterns: in women, calcium metabolism abnormalities were associated with EOS (OR 1.74) and older age at diagnosis (β +4.91 years), and ear–nose–throat involvement was associated with older age at diagnosis (β +5.74 years). Regarding pulmonary involvement, CT-based Scadding stage II was associated with younger age at diagnosis (β −3.75 years) in women and CT-based Scadding stage IV with older age at diagnosis (β +6.57 years) in men. Conclusions: EOS accounted for 16.37% of sarcoidosis cases. Older age at diagnosis was associated with specific patterns of organ involvement, which changed gradually across the age spectrum, some of them differing by sex in exploratory analyses. Further studies are needed to confirm these findings.

Journal of Clinical MedicineVol. 15(21)
Universitat Autònoma de Barcelona (ES), Universidad de Salamanca (ES), Hospital Universitario La Paz (ES), Hospital General Universitario Gregorio Marañón (ES), Althaia (ES), Complejo Hospitalario de Salamanca (ES), Hospital Universitario 12 De Octubre (ES), Hospital Virgen de la Salud (ES), Institut d'Investigació Biomèdica de Girona (ES), Hospital Clínic de Barcelona (ES), Corporació Sanitària Parc Taulí (ES), Hospital Santa Caterina (ES), Hospital Universitario Central de Asturias (ES), Instituto de Investigación Biomédica de Salamanca (ES), Institute of Research and Innovation Parc Tauli (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Hospital Universitario De Cabueñes (ES), Hospital Universitari Joan XXIII de Tarragona (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Universitari de Girona Doctor Josep Trueta (ES), Hospital Universitario Ramón y Cajal (ES), Hospital Universitario Infanta Leonor (ES), Hospital Sanitas CIMA (ES), Universitat de Barcelona (ES), Chartered Institute of Management Accountants (GB)
Good health and well-being
Openalex Percentile: Top 13%
Sarcoidosis and Beryllium Toxicity Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Laika access coming soon