CFD Analysis of Coronary Artery Blood Flow Using an Ad Hoc OpenFOAM CFD Solver

Coronary blood flow is governed by the interaction between pulsatile aortic haemodynamics, the downstream vascular response, and the time-dependent compression exerted by the myocardium. This study presents a custom OpenFOAM solver for simulation of aortic–coronary haemodynamics. The numerical framework combines a power-law inlet velocity profile selected according to the estimated Womersley regime, a three-element Windkessel condition at the aortic outlet, and dedicated lumped-parameter boundary conditions at the coronary outlets, including the effect of intramyocardial pressure. The methodology was applied to two patient-specific aortic–coronary geometries reconstructed from computed tomography data. Numerical discretisation uncertainty was assessed using three mesh resolutions, while the spatial resolution of the detached-eddy simulation was examined by comparing modelled and resolved kinetic-energy contributions. The methodology developed reproduced pulsatile velocity and pressure fields, geometry-dependent recirculation patterns, and distinct pressure responses along the aortic and coronary pathways. Computed velocity and pressure magnitudes were of the same physiological scale as available in vivo coronary measurements. The proposed framework provides a computational methodology for investigating local haemodynamics in patient-specific aortic–coronary anatomies while accounting for the downstream coronary circulation and intramyocardial effects.

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Publication Details

Journal
Applied Sciences
Published
2026-10-27
DOI
https://doi.org/10.3390/app162110635
Primary Topic
Cardiac Imaging and Diagnostics
Type
article
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article

CFD Analysis of Coronary Artery Blood Flow Using an Ad Hoc OpenFOAM CFD Solver

Francesco Duronio, Luca Di Angelo, Andrea Di Mascio, Elena Iovannitti et al.
Applied Sciences
Cardiac Imaging and Diagnostics
article

CFD Analysis of Coronary Artery Blood Flow Using an Ad Hoc OpenFOAM CFD Solver

Francesco Duronio, Luca Di Angelo, Andrea Di Mascio, Elena Iovannitti, Beatrice Sette
article en

Abstract

Coronary blood flow is governed by the interaction between pulsatile aortic haemodynamics, the downstream vascular response, and the time-dependent compression exerted by the myocardium. This study presents a custom OpenFOAM solver for simulation of aortic–coronary haemodynamics. The numerical framework combines a power-law inlet velocity profile selected according to the estimated Womersley regime, a three-element Windkessel condition at the aortic outlet, and dedicated lumped-parameter boundary conditions at the coronary outlets, including the effect of intramyocardial pressure. The methodology was applied to two patient-specific aortic–coronary geometries reconstructed from computed tomography data. Numerical discretisation uncertainty was assessed using three mesh resolutions, while the spatial resolution of the detached-eddy simulation was examined by comparing modelled and resolved kinetic-energy contributions. The methodology developed reproduced pulsatile velocity and pressure fields, geometry-dependent recirculation patterns, and distinct pressure responses along the aortic and coronary pathways. Computed velocity and pressure magnitudes were of the same physiological scale as available in vivo coronary measurements. The proposed framework provides a computational methodology for investigating local haemodynamics in patient-specific aortic–coronary anatomies while accounting for the downstream coronary circulation and intramyocardial effects.

Applied SciencesVol. 16(21)
University of L'Aquila (IT)
Good health and well-being
Openalex Percentile: Top 13%
Cardiac Imaging and Diagnostics
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CFD Analysis of Coronary Artery Blood Flow Using an Ad Hoc OpenFOAM CFD Solver — Francesco Duronio, Luca Di Angelo, et al. · Applied Sciences (2026) | TGRS Research Map | TGRS