Conserved spike epitopes persist in generalist bat sarbecoviruses

Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. Two new studies in PLOS Biology link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.

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Publication Details

Journal
PLoS Biology
Published
2026-10-27
DOI
https://doi.org/10.1371/journal.pbio.3004071
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Conserved spike epitopes persist in generalist bat sarbecoviruses

Matthew B. Frieman
2 links
PLoS Biology
SARS-CoV-2 and COVID-19 Research
article

Conserved spike epitopes persist in generalist bat sarbecoviruses

Matthew B. Frieman
article en

Abstract

Bat sarbecoviruses differ in the range of mammalian ACE2 receptors they can use, complicating predictions of spillover risk. Two new studies in PLOS Biology link receptor breadth with antigenic relatedness and reveal conserved spike epitopes targetable by antibodies.

PLoS BiologyVol. 24(10)
University of Maryland, Baltimore (US)
Openalex Percentile: Top 12%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
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Conserved spike epitopes persist in generalist bat sarbecoviruses — Matthew B. Frieman · PLoS Biology (2026) | TGRS Research Map | TGRS