One factor, two safeguards: RUNX1 divides its labor across the regulatory genome
Fritz et al. 1 1. Fritz, A.J. ∙ Greenyer, H. ∙ Dillac, L. ... Acute degron-mediated RUNX1 loss epigenetically reprograms enhancers associated with epithelial destabilization and initiation of cancer hallmarks Cell Rep. 2026; 45 , 118129 Full Text Full Text (PDF) Scopus (0) PubMed Google Scholar use acute RUNX1 degradation to reveal how mammary epithelial cells maintain their state. RUNX1 links enhancer-centered control of epithelial identity with promoter-centered control of DNA-damage responsiveness.
Authors
- Reo Maruyama (ORCID: https://orcid.org/0000-0001-7166-5964)
- Kenichi Miyata (ORCID: https://orcid.org/0000-0002-8618-3105)
- Yuta Uneme
Institutions
- Japanese Foundation For Cancer Research (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-10-27
- DOI
- https://doi.org/10.1016/j.celrep.2026.118129
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00