Mathematical modeling of biological systems using differential equations

Nonlinear interactions and temporal evolution in a biological system can be mathematically modeled by differential equations and can be analysed quantitatively.Combining biologically relevant growth, mortality, resource limitation, interaction, regulation, equilibrium, stability and numerical solution mechanisms, this study suggests an integrated framework.The novelty is to combine the three elements of nonlinear biological dynamics, Jacobian-based stability assessment, and comparative numerical evaluation, in a coherent modeling framework.The Euler, Heun, Midpoint, third-order Runge-Kutta (RK3) and fourth-order Runge-Kutta (RK4) methods were compared at a step size of 0.10.The results show that RK4 gives the highest accuracy of 98.8%, with the lowest RMSE of 0.012, and the lowest absolute error of 0.009 when compared to Euler with 91.6% accuracy and RMSE of 0.084.RK3 achieved 97.5% accuracy with 0.025 RMSE.These results confirm numerical reliability for studying nonlinear dynamics, equilibrium behavior, stability and responses of systems as a function of their parameters.

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Publication Details

Journal
Journal of Interdisciplinary Mathematics
Published
2026-10-27
DOI
https://doi.org/10.47974/jim-2836
Primary Topic
Mathematical and Theoretical Epidemiology and Ecology Models
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article
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article

Mathematical modeling of biological systems using differential equations

Rahul Mishra, Satish Kakade, Swapnil Chaudhary, Makineedi Babu et al.
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Journal of Interdisciplinary Mathematics
Mathematical and Theoretical Epidemiology and Ecology Models
article

Mathematical modeling of biological systems using differential equations

Rahul Mishra, Satish Kakade, Swapnil Chaudhary, Makineedi Babu, Vinod Naidu Pamuluri, Madhur Taneja, H. Savithri
article en

Abstract

Nonlinear interactions and temporal evolution in a biological system can be mathematically modeled by differential equations and can be analysed quantitatively.Combining biologically relevant growth, mortality, resource limitation, interaction, regulation, equilibrium, stability and numerical solution mechanisms, this study suggests an integrated framework.The novelty is to combine the three elements of nonlinear biological dynamics, Jacobian-based stability assessment, and comparative numerical evaluation, in a coherent modeling framework.The Euler, Heun, Midpoint, third-order Runge-Kutta (RK3) and fourth-order Runge-Kutta (RK4) methods were compared at a step size of 0.10.The results show that RK4 gives the highest accuracy of 98.8%, with the lowest RMSE of 0.012, and the lowest absolute error of 0.009 when compared to Euler with 91.6% accuracy and RMSE of 0.084.RK3 achieved 97.5% accuracy with 0.025 RMSE.These results confirm numerical reliability for studying nonlinear dynamics, equilibrium behavior, stability and responses of systems as a function of their parameters.

Journal of Interdisciplinary MathematicsVol. 29(10)
Krishna Institute of Medical Sciences Deemed University (IN), Rungta College of Engineering and Technology (IN), Dayananda Sagar College of Engineering (IN), Aditya University (IN), Chitkara University (IN)
Openalex Percentile: Top 10%
Mathematical and Theoretical Epidemiology and Ecology Models
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Mathematical modeling of biological systems using differential equations — Rahul Mishra, Satish Kakade, et al. · Journal of Interdisciplinary Mathematics (2026) | TGRS Research Map | TGRS