Lysosomal acidification through membrane contacts with mitochondria
Recent work from two independent studies has uncovered mitochondria as a previously unrecognized proton source driving lysosomal acidification. In this Viewpoint, we summarize these findings, examine the associated proteins and functional mechanisms, and discuss their relevance to disease.
Authors
- Yujie Sun (ORCID: https://orcid.org/0000-0002-4122-6255)
- Jiajie Diao (ORCID: https://orcid.org/0000-0003-4288-3203)
- Zhiqi Tian (ORCID: https://orcid.org/0000-0001-7027-9527)
Institutions
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2026-10-27
- DOI
- https://doi.org/10.1083/jcb.202606052
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health