Sensitive Level of Detection of Heavy Metals by Using PDA Detector in API and Formulation of Simvastatin

A simple, rapid and sensitive ultra-fast liquid chromatographic technique was developed for the determination of heavy metals in pharmaceutical dosage form. Lead and copper were detected and quantified at µg level in simvastatin, a pharmaceutical product used in the treatment of lowering cholesterol level in body. Calcium disodium edetate was used as the chelating agent.