Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action
Over the past 25 years, considerable progress has been made in identifying the prevalence, risk factors, functional impacts, and protective strategies for cisplatin-induced ototoxicity. Despite these advances, ototoxicity monitoring and audiologic management of children undergoing cisplatin treatment remains inconsistent across clinical settings. This position paper from the German-Indonesian Society for Medicine (DIGM) Ototoxicity Working Group reflects a consensus process based on expert opinion, supported by a narrative review of the scientific literature and recently published recommendations regarding audiologic management of children receiving cisplatin chemotherapy. We advocate that ototoxicity monitoring be recognized as standard of care for every child receiving cisplatin and incorporated into pediatric cancer treatment protocols. This paper proposes a minimum benchmark for the audiologic management of children undergoing cisplatin chemotherapy; a standard that can be readily implemented in most clinical settings worldwide.
Authors
- Alex E. Hoetink (ORCID: https://orcid.org/0000-0002-7417-5546)
- Nyilo Purnami (ORCID: https://orcid.org/0000-0001-9572-2679)
- Asmarinah Asmarinah (ORCID: https://orcid.org/0000-0001-5204-4054)
- Anna‐Katharina Rohlfs (ORCID: https://orcid.org/0000-0003-4689-4102)
- Helen Alexandra Spoudeas (ORCID: https://orcid.org/0000-0002-0774-6601)
- Murti Andriastuti (ORCID: https://orcid.org/0000-0003-2258-6877)
- Marry M. van den Heuvel‐Eibrink (ORCID: https://orcid.org/0000-0002-7760-879X)
- Penelope Rachel Brock (ORCID: https://orcid.org/0000-0003-1239-6316)
- Milanka Drenovak
- Cimi Ilmiawati (ORCID: https://orcid.org/0000-0001-5743-3331)
- Haldun Oğuz (ORCID: https://orcid.org/0000-0003-2106-4735)
- Thorsten Langer (ORCID: https://orcid.org/0000-0002-7047-2957)
- Kaukab M. Rajput (ORCID: https://orcid.org/0000-0002-6155-9372)
- Kristin R. Knight (ORCID: https://orcid.org/0000-0002-5701-3537)
- Ika Dewi Mayangsari (ORCID: https://orcid.org/0000-0003-1851-4520)
- Antoinette am Zehnhoff‐Dinnesen (ORCID: https://orcid.org/0000-0002-6146-1500)
- Nienke Streefkerk (ORCID: https://orcid.org/0009-0001-3362-6953)
- Deborah Berndtson
- Tri Juda Airlangga
- Irene Schmid (ORCID: https://orcid.org/0000-0002-5105-3597)
- Rasjid Soeparwata
- Kim E. de Jager (ORCID: https://orcid.org/0000-0001-9422-4897)
- Dawn Konrad Martin
- Shally Adhina Putri
- M. Tayyar Kalcioglu
- Adwina Nurlita Kusuma Wardhani Hartantyo
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Oregon Health & Science University (US)
- Universitas Airlangga (ID)
- University of Münster (DE)
- Great Ormond Street Hospital (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Portland VA Medical Center (US)
- University of Indonesia (ID)
- University Medical Center Utrecht (NL)
- University Hospital Münster (DE)
- National Center for PTSD (US)
- Princess Máxima Center (NL)
- Lokman Hekim Üniversitesi (TR)
- VA Portland Health Care System (US)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Doernbecher Children's Hospital (US)
- Eastman Dental Hospital (GB)
- Andalas University (ID)
- Istanbul Medeniyet University (TR)
- FH Münster University of Applied Sciences (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-10-27
- DOI
- https://doi.org/10.3389/fonc.2026.1923166
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00