The history of therapeutic EUS

The invention of linear echoendoscopes in the early 1990s marked the start of the evolution of EUS from a purely diagnostic modality into a cornerstone of minimally invasive endoscopic therapy. Early innovations in imaging and needle design laid the groundwork for EUS-guided drainage of pancreatic fluid collections. Over time, these advances have enabled a wide range of therapeutic applications, including biliary, gallbladder, and pancreatic duct drainage, neurolysis, tumor ablation, and enteral access. Moreover, the development of dedicated therapeutic echoendoscopes with a large working channel, specialized stents designed for EUS-guided deployment, and EUS-specific tools (e.g., micro forceps and radiofrequency probes) have expanded the role of EUS into areas once dominated by surgery. This historical review highlights key technological milestones, pivotal studies, and clinical applications that have shaped the evolution of therapeutic EUS and continue to define its expanding role in interventional endoscopy.

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Publication Details

Journal
Endoscopic Ultrasound
Published
2026-10-27
DOI
https://doi.org/10.1097/eus.0000000000000203
Primary Topic
Gallbladder and Bile Duct Disorders
Type
article
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article

The history of therapeutic EUS

Christian Jenssen, Yasunobu Yamashita, Manoop S. Bhutani, Masayuki Kitano et al.
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Endoscopic Ultrasound
Gallbladder and Bile Duct Disorders
article

The history of therapeutic EUS

Christian Jenssen, Yasunobu Yamashita, Manoop S. Bhutani, Masayuki Kitano, Pietro Fusaroli, Barbara Braden, Bojan Kovacevic, ChristophF Dietrich, Peter Vilmann, Kenneth Frank Binmoeller, H Seifert, Siyu Sun
article en

Abstract

The invention of linear echoendoscopes in the early 1990s marked the start of the evolution of EUS from a purely diagnostic modality into a cornerstone of minimally invasive endoscopic therapy. Early innovations in imaging and needle design laid the groundwork for EUS-guided drainage of pancreatic fluid collections. Over time, these advances have enabled a wide range of therapeutic applications, including biliary, gallbladder, and pancreatic duct drainage, neurolysis, tumor ablation, and enteral access. Moreover, the development of dedicated therapeutic echoendoscopes with a large working channel, specialized stents designed for EUS-guided deployment, and EUS-specific tools (e.g., micro forceps and radiofrequency probes) have expanded the role of EUS into areas once dominated by surgery. This historical review highlights key technological milestones, pivotal studies, and clinical applications that have shaped the evolution of therapeutic EUS and continue to define its expanding role in interventional endoscopy.

Endoscopic Ultrasound
Goethe University Frankfurt (DE), The University of Texas MD Anderson Cancer Center (US), Wakayama Medical University (JP), Sheng Jing Hospital (CN), California Pacific Medical Center (US), Herlev Hospital (DK), Copenhagen University Hospital (DK), Gentofte Hospital (DK), Krankenhaus Märkisch-Oderland (DE), University Hospital Münster (DE), Klinikum Oldenburg (DE), University Hospital Frankfurt (DE), Medizinische Hochschule Brandenburg Theodor Fontane (DE), China Medical University (CN), University of Bologna (IT)
Good health and well-being
Openalex Percentile: Top 12%
Gallbladder and Bile Duct Disorders
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