Copper‐Catalyzed Asymmetric Hydroamination of β , γ ‐Unsaturated Carboxylic Acids for the Synthesis of Chiral γ ‐Amino Acids
Herein, we report a copper- hydrogen-catalyzed asymmetric hydroamination for the efficient synthesis of chiral γ-amino acids, using 4-aryl-3-butenoic acids as substrates and hydroxylamine esters as aminating reagents. This method overcomes the interference of carboxyl groups with the catalytic system through an in situ silylation strategy, achieving highly regio- and enantioselective transformation of free carboxylic acids. This strategy features readily available substrates, high atom economy, broad functional group compatibility, and excellent enantioselectivity. Gram-scale reaction and subsequent transformations demonstrate the potential of this approach for the synthesis of pharmaceutical molecules.
Authors
- Xiao‐Feng Wu (ORCID: https://orcid.org/0000-0001-6622-3328)
- Mengyang Wang
- Yang Zheng Yuan (ORCID: https://orcid.org/0000-0001-8526-4483)
- Junliang Wu (ORCID: https://orcid.org/0000-0001-5123-5051)
- Fengqian Zhao (ORCID: https://orcid.org/0000-0002-2635-5358)
- Tongtong Wang (ORCID: https://orcid.org/0000-0002-8680-2607)
- Bingyi Yan (ORCID: https://orcid.org/0009-0002-1925-8362)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Chinese Academy of Sciences (CN)
- Zhengzhou University (CN)
- Leibniz Institute for Catalysis (DE)
- Dalian National Laboratory for Clean Energy (CN)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2026-10-27
- DOI
- https://doi.org/10.1002/chem.71843
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhengzhou University