CLDN18.2 ADCs “A Real Step Forward” for Stomach Cancer

Results from two phase III trials, CLARITY-Gastric01 and G-HOPE-001, indicate that the investigational CLDN18.2-targeting antibody-drug conjugates sonesitatug vedotin and arcotatug tavatecan could be effective third- or later-line treatments for patients with CLDN18.2-positive gastric or gastroesophageal carcinomas. Both ADCs improved overall survival, which is welcome news for a population whose options are otherwise very limited.

Publication Details

Journal
Cancer Discovery
Published
2026-10-27
DOI
https://doi.org/10.1158/2159-8290.cd-nw2026-0100
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
Field-Weighted Citation Impact
0.00
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article

CLDN18.2 ADCs “A Real Step Forward” for Stomach Cancer

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Cancer Discovery
Gastric Cancer Management and Outcomes
article

CLDN18.2 ADCs “A Real Step Forward” for Stomach Cancer

article en

Abstract

Results from two phase III trials, CLARITY-Gastric01 and G-HOPE-001, indicate that the investigational CLDN18.2-targeting antibody-drug conjugates sonesitatug vedotin and arcotatug tavatecan could be effective third- or later-line treatments for patients with CLDN18.2-positive gastric or gastroesophageal carcinomas. Both ADCs improved overall survival, which is welcome news for a population whose options are otherwise very limited.

Cancer Discovery
Good health and well-being
Openalex Percentile: Top 12%
Gastric Cancer Management and Outcomes
DOISourceOpenAlex
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CLDN18.2 ADCs “A Real Step Forward” for Stomach Cancer · Cancer Discovery (2026) | TGRS Research Map | TGRS