Fisetin in Dermatology and Skin Care: Current Perspectives

Fisetin is a non-glycosidic flavone, a naturally occurring compound belonging to a relatively small subgroup of 5-deoxyflavonoids. It is commonly found in plants of the Fabaceae and Anacardiaceae families. Dietary sources of fisetin include various fruits and vegetables; however, the most commonly utilized natural sources for commercial fisetin extraction are Cotinus coggygria and Toxicodendron succedaneum. In recent years, fisetin has attracted the attention of researchers due to its senolytic, anti-inflammatory, antioxidant, cardioprotective, neuroprotective, and antimicrobial activities. The potential of fisetin in cancer therapy, including the treatment of melanoma, and in slowing the progression of psoriasis is also being explored. This paper provides an overview of the pharmacological effects of fisetin, with a particular focus on its potential use in the prevention and treatment of dermatological diseases and in maintaining young and healthy skin. Data on the plant sources, physicochemical properties, and bioavailability of fisetin are also presented.