Cytotoxicity and biodistribution of nanoparticles in C. elegans (compiled protocols for polystyrene nanoparticles) v1

Compiled document that groups four protocols on polystyrene nanoparticles (PS-NPs): (1) physicochemical characterization of amine- and carboxylate-modified fluorescent PS-NPs; (2) cell growth and cytotoxicity in HEK 293 cells; (3) imaging of NP uptake and the effect of the protein corona; and (4) a C. elegans study assessing acute toxicity, biodistribution, reproduction, development, pharyngeal activity and locomotion of PS-NPs in Caenorhabditis elegans.

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Publication Details

Published
2026-10-26
DOI
https://doi.org/10.17504/protocols.io.jyl8nrqe7l2w/v1
Primary Topic
Nanoparticle-Based Drug Delivery
Type
preprint
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preprint

Cytotoxicity and biodistribution of nanoparticles in C. elegans (compiled protocols for polystyrene nanoparticles) v1

Luisa Diomede
Nanoparticle-Based Drug Delivery
preprint

Cytotoxicity and biodistribution of nanoparticles in C. elegans (compiled protocols for polystyrene nanoparticles) v1

Luisa Diomede
preprint en

Abstract

Compiled document that groups four protocols on polystyrene nanoparticles (PS-NPs): (1) physicochemical characterization of amine- and carboxylate-modified fluorescent PS-NPs; (2) cell growth and cytotoxicity in HEK 293 cells; (3) imaging of NP uptake and the effect of the protein corona; and (4) a C. elegans study assessing acute toxicity, biodistribution, reproduction, development, pharyngeal activity and locomotion of PS-NPs in Caenorhabditis elegans.

Nanoparticle-Based Drug Delivery
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Cytotoxicity and biodistribution of nanoparticles in C. elegans (compiled protocols for polystyrene nanoparticles) v1 — Luisa Diomede · (2026) | TGRS Research Map | TGRS