Natural Occurrence of Primate SLAM-Adapted Canine Distemper Virus, Brazil, 2018

We analyzed canine distemper virus (CDV) from a 2018 marmoset disease outbreak in Brazil. CDV hemagglutinin protein bound to the marmoset SLAM (signaling lymphocytic activation molecule) receptor through 2 amino acid substitutions within hemagglutinin, which also enhanced human SLAM receptor usage. Continued surveillance will be critical to monitor CDV cross-species transmission.

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Publication Details

Journal
Emerging infectious diseases
Published
2026-10-27
DOI
https://doi.org/10.3201/eid3212.260946
Primary Topic
Virology and Viral Diseases
Type
article
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article

Natural Occurrence of Primate SLAM-Adapted Canine Distemper Virus, Brazil, 2018

Hekai Yang, Fumio Seki, Makoto Takeda, Mizuki Tominaga et al.
4 links
Emerging infectious diseases
Virology and Viral Diseases
article

Natural Occurrence of Primate SLAM-Adapted Canine Distemper Virus, Brazil, 2018

Hekai Yang, Fumio Seki, Makoto Takeda, Mizuki Tominaga, Shohei Kojima, Hiroshi Katoh, Yukiko Akahori, Ayumu Hyodo, Mitsuki ONODERA, Yuki Kitai
article en

Abstract

We analyzed canine distemper virus (CDV) from a 2018 marmoset disease outbreak in Brazil. CDV hemagglutinin protein bound to the marmoset SLAM (signaling lymphocytic activation molecule) receptor through 2 amino acid substitutions within hemagglutinin, which also enhanced human SLAM receptor usage. Continued surveillance will be critical to monitor CDV cross-species transmission.

Emerging infectious diseasesVol. 32(12)
Okayama University (JP), Keio University Human Biology-Microbiome-Quantum Research Center (JP), The University of Tokyo (JP)
Good health and well-being
Openalex Percentile: Top 12%
Virology and Viral Diseases
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