The association between obesity index and hypertension in type 2 diabetes: a cross-sectional study

Background The present study explored the association between the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) and hypertension in type 2 diabetes mellitus (T2DM) subjects. Methods A total of 4,155 T2DM individuals were enrolled from the Second Hospital of Shijiazhuang in this cross-sectional investigation. We employed multivariable logistic regression, restricted cubic spline (RCS) modeling, threshold effect assessment, and stratified subgroup analyses. Missing covariates were addressed through multiple imputation, while complete-case data were used for sensitivity evaluation. Results Among 4,155 participants (68.5% hypertensive), CVAI and LAP were positively associated with hypertension (P for trend < 0.001). Q4 vs. Q1 OR was 3.27 (95% CI: 2.66–4.02) for CVAI and 3.01 (95% CI: 2.43–3.72) for LAP. RCS evaluation demonstrated a significant nonlinear relationship between LAP and hypertension (P for non-linearity < 0.001), identifying a threshold value of 44.187 (95% CI: 42.141–46.233). CVAI showed linear associations in both sexes (P for non-linearity: 0.177 males, 0.055 females). Subgroup analyses showed consistent associations across strata (all P for interaction > 0.05). Conclusions CVAI and LAP are associated with hypertension in T2DM patients. LAP exhibits a nonlinear relationship with a threshold effect at approximately 44.2.

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Journal
Frontiers in Endocrinology
Published
2026-10-27
DOI
https://doi.org/10.3389/fendo.2026.1998153
Primary Topic
Diabetes, Cardiovascular Risks, and Lipoproteins
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article
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article

The association between obesity index and hypertension in type 2 diabetes: a cross-sectional study

Qianqian Zhao, Yishan Yin, Lili Zhang, Yuwei Xing et al.
2 links
Frontiers in Endocrinology
Diabetes, Cardiovascular Risks, and Lipoproteins
article

The association between obesity index and hypertension in type 2 diabetes: a cross-sectional study

Qianqian Zhao, Yishan Yin, Lili Zhang, Yuwei Xing, Xian Xiu
article en

Abstract

Background The present study explored the association between the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) and hypertension in type 2 diabetes mellitus (T2DM) subjects. Methods A total of 4,155 T2DM individuals were enrolled from the Second Hospital of Shijiazhuang in this cross-sectional investigation. We employed multivariable logistic regression, restricted cubic spline (RCS) modeling, threshold effect assessment, and stratified subgroup analyses. Missing covariates were addressed through multiple imputation, while complete-case data were used for sensitivity evaluation. Results Among 4,155 participants (68.5% hypertensive), CVAI and LAP were positively associated with hypertension (P for trend < 0.001). Q4 vs. Q1 OR was 3.27 (95% CI: 2.66–4.02) for CVAI and 3.01 (95% CI: 2.43–3.72) for LAP. RCS evaluation demonstrated a significant nonlinear relationship between LAP and hypertension (P for non-linearity < 0.001), identifying a threshold value of 44.187 (95% CI: 42.141–46.233). CVAI showed linear associations in both sexes (P for non-linearity: 0.177 males, 0.055 females). Subgroup analyses showed consistent associations across strata (all P for interaction > 0.05). Conclusions CVAI and LAP are associated with hypertension in T2DM patients. LAP exhibits a nonlinear relationship with a threshold effect at approximately 44.2.

Frontiers in EndocrinologyVol. 17
Second Hospital of Hebei Medical University (CN), Chinese People's Armed Police Force (CN)
Good health and well-being
Openalex Percentile: Top 11%
Diabetes, Cardiovascular Risks, and Lipoproteins
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The association between obesity index and hypertension in type 2 diabetes: a cross-sectional study — Qianqian Zhao, Yishan Yin, et al. · Frontiers in Endocrinology (2026) | TGRS Research Map | TGRS