Hepatoprotective role of Trigonella foenum-graecum in Paracetamol Induced Hepatotoxicity

Objectives : To evaluate the hepatoprotective activity of Trigonella foenum graecum in Paracetamol induced Hepatotoxicity. Method : The study was carried out using Swiss mice maintained under standard laboratory conditions. Animals were divided into five groups consisting of normal control, disease control (PCM-treated), standard treatment (Silymarin + PCM), fenugreek low dose (100 mg/kg + PCM), and fenugreek high dose (200 mg/kg + PCM). Results: The results revealed that Paracetamol administration produced significant hepatotoxicity, as evidenced by reductions in hematological parameters and marked elevations in serum ALT, AST, and ALP levels. The disease group showed severe liver injury compared to the normal control group. Conclusion: Treatment with aqueous extract of fenugreek at both low dose (100 mg/kg) and high dose (200 mg/kg) significantly improved these altered parameters and showed protective effects against Paracetamol-induced liver damage. The high-dose treatment exhibited comparatively greater hepatoprotective activity, suggesting a dose-dependent response. The protective effects observed may be attributed to the presence of bioactive phytoconstituents such as flavonoids, polyphenols, alkaloids, saponins, and antioxidant compounds present in fenugreek, which help in reducing oxidative stress and stabilizing hepatocellular membranes.