Temporal trends in mortality from diverticular disease of the intestine with septicemia stratified by demographics: a retrospective study

Background: Diverticular disease of the intestine is a major cause of mortality, and its association with septicemia remains underexplored. Understanding this relationship is essential to identify high-risk population and develop targeted public health interventions. The aim of the study is to analyze mortality trends and demographic disparities in diverticular disease of intestine with septicemia as a contributing cause using the CDC multiple causes of Death (MCD) database from 1999-2020. Methods: A retrospective observational study was conducted using CDC MCD database to assess mortality trends in individuals aged 25 years and older in the United States From 1999-2000. The study included deaths where diverticular disease of intestine (ICD - 10: K57) was listed as the underlying cause and septicemia (ICD-10:A44) as a contributing cause. Data were analyzed by age, gender, race, geographic region, and place of death. Age- related mortality rates (AAMR) and annual percentage change (APC) were calculated. Results: A total of 67310 Deaths were recorded. The AAMR for diverticular disease of intestine showed increase over time (APC). The highest mortality was observed in females, whites and temporal trends showed increase with disparities noted across demographic and geographic factors. Conclusions: This study highlights significant mortality trends increasing in diverticular disease of intestine with septicemia, with disparities by gender, age and location. Findings underscore the need for targeted prevention strategies and improved healthcare success.