Differential contributions of CO 2 and blood pressure to cerebral macro- and microvascular reactivity in healthy adults
This study indicates that cerebrovascular reactivity to CO 2 (CVR-CO 2 ) differs between the macro- and microcirculation during both hypocapnia and hypercapnia and that relative contributions of CO 2 and blood pressure to these responses differ between vascular compartments during hypercapnia. These findings highlight the importance of considering compartment-specific regulatory mechanisms when interpreting CVR-CO 2 .
Authors
- Junyeon Won (ORCID: https://orcid.org/0000-0001-7900-9355)
- Takuya Kurazumi (ORCID: https://orcid.org/0000-0001-5218-2414)
- Danilo Cardim (ORCID: https://orcid.org/0000-0002-9261-1321)
- Kartavya Sharma (ORCID: https://orcid.org/0000-0003-0073-5915)
- Tsubasa Tomoto (ORCID: https://orcid.org/0000-0001-5936-0332)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-6534-5216)
Institutions
- Nihon University (JP)
- Mayo Clinic (US)
- Texas Health Dallas (US)
- San-ikukai Hospital (JP)
- Fukujuji Hospital (JP)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- American Journal of Physiology-Heart and Circulatory Physiology
- Published
- 2026-10-26
- DOI
- https://doi.org/10.1152/ajpheart.90012.2026
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Aging
- National Heart, Lung, and Blood Institute