Effect of diet-induced plasma ceramide on human in vivo microvascular endothelial function
Acute consumption of a long-chain fatty acid-rich meal increased circulating ceramides in a sex-specific manner, with elevations observed only in females. Despite this, in vivo microvascular endothelial function was similarly impaired after both medium- and long-chain fatty acid-rich meals, with no differences observed between sexes. Further studies are needed to define the role of ceramide-induced microvascular dysfunction and the long-term cardiovascular impact of repeated exposure.
Authors
- Gopika SenthilKumar (ORCID: https://orcid.org/0000-0001-5781-1056)
- Kai Yang (ORCID: https://orcid.org/0000-0003-3044-2240)
- Julie K. Freed (ORCID: https://orcid.org/0000-0002-9367-2281)
- Tijana Simovic (ORCID: https://orcid.org/0000-0002-3613-4196)
- Matthew J. Durand (ORCID: https://orcid.org/0000-0002-1416-1652)
- Maria Jose Jaramillo-Torres (ORCID: https://orcid.org/0009-0008-2033-0273)
- Emily O’Connell (ORCID: https://orcid.org/0009-0003-7330-3467)
- Haoran Teng
- William Butak (ORCID: https://orcid.org/0009-0005-5493-5295)
Institutions
- Medical College of Wisconsin (US)
Publication Details
- Journal
- American Journal of Physiology-Heart and Circulatory Physiology
- Published
- 2026-10-26
- DOI
- https://doi.org/10.1152/ajpheart.90085.2026
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute