Efficacy and safety of trans-fornix conjunctival retrobulbar block in a prospective randomized controlled trial

Retrobulbar block is widely used for vitreoretinal surgery, but the conventional transcutaneous technique advances a sharp needle blindly through the lower eyelid. We evaluated a trans -fornix conjunctival approach in which a curved blunt-tip needle is advanced into the muscle cone under the operating microscope. In a two-center randomized trial, 196 patients were stratified by expected surgical duration and allocated to the transcutaneous or the trans -fornix technique, and pain was graded at predefined procedural stages. The trans -fornix approach reduced pain during anesthetic injection in both cohorts and during scleral indentation in longer procedures, and fewer patients required supplemental anesthesia. Ocular akinesia was better with the trans -fornix technique, and periorbital hemorrhage and ecchymosis occurred only in the transcutaneous group. These findings support the trans -fornix block as a practical and reproducible option for regional anesthesia in vitreoretinal surgery.

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Publication Details

Journal
iScience
Published
2026-10-26
DOI
https://doi.org/10.1016/j.isci.2026.118026
Primary Topic
Anesthesia and Pain Management
Type
article
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article

Efficacy and safety of trans-fornix conjunctival retrobulbar block in a prospective randomized controlled trial

Tao Xu, Kejun Liu, Chunyan Xi, Ruibo Chen et al.
iScience
Anesthesia and Pain Management
article

Efficacy and safety of trans-fornix conjunctival retrobulbar block in a prospective randomized controlled trial

Tao Xu, Kejun Liu, Chunyan Xi, Ruibo Chen, Guorong Shi, Mengqing Yin, Kai Hu, Ruirui Chen, Bing Chen, Chunming Chen
article en

Abstract

Retrobulbar block is widely used for vitreoretinal surgery, but the conventional transcutaneous technique advances a sharp needle blindly through the lower eyelid. We evaluated a trans -fornix conjunctival approach in which a curved blunt-tip needle is advanced into the muscle cone under the operating microscope. In a two-center randomized trial, 196 patients were stratified by expected surgical duration and allocated to the transcutaneous or the trans -fornix technique, and pain was graded at predefined procedural stages. The trans -fornix approach reduced pain during anesthetic injection in both cohorts and during scleral indentation in longer procedures, and fewer patients required supplemental anesthesia. Ocular akinesia was better with the trans -fornix technique, and periorbital hemorrhage and ecchymosis occurred only in the transcutaneous group. These findings support the trans -fornix block as a practical and reproducible option for regional anesthesia in vitreoretinal surgery.

iScienceVol. 29(11)
Xiamen University (CN), Wenzhou Medical University (CN), Affiliated Eye Hospital of Wenzhou Medical College (CN), Nanjing Drum Tower Hospital (CN), He Eye Hospital (CN), Southeast University (CN), Nanjing University (CN)
Openalex Percentile: Top 10%
Anesthesia and Pain Management
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Efficacy and safety of trans-fornix conjunctival retrobulbar block in a prospective randomized controlled trial — Tao Xu, Kejun Liu, et al. · iScience (2026) | TGRS Research Map | TGRS