Light-regulated biomaterial interfaces enable flexible neural bioelectronics with stable adhesion and on-demand detachment for chronic electrophysiology

Dynamic bioelectronic interfaces are required to simultaneously ensure stable tissue integration for chronic recording and controllable debonding for device reconfiguration or retrieval. This challenge is particularly acute for implantable neural interfaces, where weak adhesion compromises signal fidelity, while permanent adhesion may cause secondary tissue damage during removal. Here, we developed a photo-programmable neural biointerface incorporating a self-healing bPDMS@Fe matrix based on a carboxyl-functionalized polydimethylsiloxane network dynamically crosslinked by Fe 3+ -carboxylate coordination. The resulting electrode exhibits robust adhesion to diverse substrates and biological tissues, as well as on-demand removal through UV-induced adhesion weakening. Moreover, it supports stable epidermal electrocardiogram recording under various conditions. Furthermore, the biointerface is translated into a 9-channel cortical electrode array that enables stable local field potential recording and spatiotemporal mapping of seizure-associated neural activity in freely moving mice. This work establishes a dynamic adhesive strategy as a new materials design paradigm for neural bioelectronic interfaces toward next-generation chronic electrophysiological monitoring devices.