Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF2H as transmetalation reagent

A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF2H as CF2H source. A variety of electronically diverse arenes was smoothly transformed and the reaction displayed excellent levels of chemoselectivity, tolerating inter alia synthetically valuable triflates.

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Publication Details

Journal
DepositOnce
Published
2026-10-26
DOI
https://doi.org/10.14279/depositonce-25894
Primary Topic
Fluorine in Organic Chemistry
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article
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article

Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF2H as transmetalation reagent

Torben Rogge
DepositOnce
Fluorine in Organic Chemistry
article

Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF2H as transmetalation reagent

Torben Rogge
article en

Abstract

A user-friendly method for the difluoromethylation of aryl iodides under nickel catalysis has been developed, employing readily accessible, light- and temperature-insensitive (SIPr)AgCF2H as CF2H source. A variety of electronically diverse arenes was smoothly transformed and the reaction displayed excellent levels of chemoselectivity, tolerating inter alia synthetically valuable triflates.

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Fluorine in Organic Chemistry
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Chemoselective nickel-catalyzed difluoromethylation of aryl halides with (SIPr)AgCF2H as transmetalation reagent — Torben Rogge · DepositOnce (2026) | TGRS Research Map | TGRS