Pulmonary Sarcoidosis Mimicking Multifocal Adenocarcinoma: An Atypical Radiologic and Diagnostic Dilemma

Known as "the great mimic," sarcoidosis often poses a diagnostic challenge.Although common radiological manifestations include hilar and mediastinal lymphadenopathy and micronodules, atypical patterns can also be encountered, requiring awareness of the disease's potential radiological manifestations to allow for prompt diagnosis and management.We report a case of sarcoidosis presenting with predominant groundglass opacities (GGOs) on high-resolution CT (HRCT) of the chest, mimicking adenocarcinoma in situ.The diagnosis was established by histopathology after other causes of pulmonary GGOs had been excluded.This report highlights the importance of maintaining a high degree of clinical suspicion and pursuing a comprehensive workup, including tissue diagnosis, even in minimally symptomatic patients.

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Publication Details

Journal
Cureus
Published
2026-10-26
DOI
https://doi.org/10.7759/cureus.118626
Primary Topic
Sarcoidosis and Beryllium Toxicity Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Pulmonary Sarcoidosis Mimicking Multifocal Adenocarcinoma: An Atypical Radiologic and Diagnostic Dilemma

JEHAD J AZAR, Alaa Hmeedan, Muhammad Naeem, Ashraf Saeed et al.
Cureus
Sarcoidosis and Beryllium Toxicity Research
article

Pulmonary Sarcoidosis Mimicking Multifocal Adenocarcinoma: An Atypical Radiologic and Diagnostic Dilemma

JEHAD J AZAR, Alaa Hmeedan, Muhammad Naeem, Ashraf Saeed, Aya Gohar
article en

Abstract

Known as "the great mimic," sarcoidosis often poses a diagnostic challenge.Although common radiological manifestations include hilar and mediastinal lymphadenopathy and micronodules, atypical patterns can also be encountered, requiring awareness of the disease's potential radiological manifestations to allow for prompt diagnosis and management.We report a case of sarcoidosis presenting with predominant groundglass opacities (GGOs) on high-resolution CT (HRCT) of the chest, mimicking adenocarcinoma in situ.The diagnosis was established by histopathology after other causes of pulmonary GGOs had been excluded.This report highlights the importance of maintaining a high degree of clinical suspicion and pursuing a comprehensive workup, including tissue diagnosis, even in minimally symptomatic patients.

Cureus
Ain Shams University (EG), An-Najah National University (PS), SUNY Upstate Medical University (US), Mayo Clinic in Arizona (US), Mayo Clinic Hospital (US)
Openalex Percentile: Top 13%
Sarcoidosis and Beryllium Toxicity Research
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Pulmonary Sarcoidosis Mimicking Multifocal Adenocarcinoma: An Atypical Radiologic and Diagnostic Dilemma — JEHAD J AZAR, Alaa Hmeedan, et al. · Cureus (2026) | TGRS Research Map | TGRS