Associations of the Baseline Level and Change in Triglyceride Glucose‐Body Roundness Index With Cardiovascular Diseases: Two Large Prospective Cohorts in Europe and Asia

ABSTRACT The aim of this study was to investigate the association of baseline and changes of TyG‐BRI with incident CVD based on the UK Biobank and China Health and Retirement Longitudinal Study (CHARLS). A total of 418,510 and 7923 individuals from the UK Biobank and CHARLS were included in Analysis 1 (baseline TyG‐BRI with CVD risk). In Analysis 2 (change in TyG‐BRI with CVD risk), a total of 11,682 and 4637 participants were included in Cox proportional hazard models. We found participants with the highest baseline TyG‐BRI level were associated with increased risk of incident CVD in UK Biobank (HR = 1.45, 95% CI: 1.39–1.52) and CHARLS (HR = 1.35, 95% CI: 1.13–1.61). Multivariable‐adjusted restricted cubic spline analyses presented positive linear associations between TyG‐BRI and CVD risk. Compared to persistently low levels of TyG‐BRI (Class 1), those with persistently high levels (Class 3: 1.23 (1.02–1.49) and 1.42 (1.11–1.55); Class 4: 1.48 (1.17–1.87) and 1.45 (1.16–2.28); Class 5: 2.58 (1.86–3.58) and 1.63 (1.16–2.28) for UK Biobank and CHARLS) in follow‐up were associated with increased risks of incident CVD. In conclusion, a high baseline TyG‐BRI level and different changes in TyG‐BRI level are associated with increased risks of incident CVD.