Filling the Gap: A Multicenter Evaluation of Listeriosis and Mortality Predictors in Türkiye

The aim of this study was to characterize invasive listeriosis in Türkiye and identify predictors of in-hospital mortality. This multicenter retrospective observational study included adult patients with laboratory-confirmed Listeria monocytogenes infection from 26 centers between 2015 and 2024. Clinical, demographic, laboratory, and treatment data were collected. Patients were classified based on infection type. Univariate analyses were followed by multivariable logistic regression to determine independent predictors of mortality. A total of 129 patients were included (mean age 62.1 ± 16.9 years; 65.9% male). The in-hospital mortality rate was 54.8%. Deceased patients were older and had more frequent comorbidities. Bacteremia without central nervous system involvement was more common among nonsurvivors. Lower Glasgow Coma Scale (GCS) scores, lower platelet counts, higher CRP levels, and more frequent blood culture positivity were observed in patients who died. In multivariable analyses, higher GCS scores were associated with lower odds of mortality (adjusted odds ratio [OR] 0.71 per 1-point increase, 95% confidence interval [CI] 0.59–0.86), as were higher platelet counts (adjusted OR: 0.94 per 10,000/µL increase, 95% CI: 0.89–0.99), whereas blood culture positivity was associated with higher odds of mortality (adjusted OR: 3.19, 95% CI: 1.04–9.82). Invasive listeriosis is associated with high mortality in Türkiye. Admission GCS score, platelet count, and blood culture positivity were independently associated with mortality and may help identify patients at increased risk of death.

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Journal
Foodborne Pathogens and Disease
Published
2026-10-22
DOI
https://doi.org/10.1177/15353141261501295
Primary Topic
Listeria monocytogenes in Food Safety
Type
article
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article

Filling the Gap: A Multicenter Evaluation of Listeriosis and Mortality Predictors in Türkiye

Taliha Karakök, Ayşe Şenbaba Kara, Halime Araz, Murat Aydın et al.
Foodborne Pathogens and Disease
Listeria monocytogenes in Food Safety
article

Filling the Gap: A Multicenter Evaluation of Listeriosis and Mortality Predictors in Türkiye

Taliha Karakök, Ayşe Şenbaba Kara, Halime Araz, Murat Aydın, Merve Büyükkörük, Ceren Atasoy Tahtasakal, Yasemin Çakır Kıymaz, Hüseyin Esmer, Selcen Özer Kökkızıl, Sibel Yıldız Kaya, Fatih Temoçin, Semanur Kuzi, Elif Agüloğlu Bali, İlkay Nur Can, Pelin İrkören, Tuba Kuruoğlu, Derya Seyman, Serhat Atalar, Turan Aslan, Murat Hakan Kır, Esra Kaya Kılıç, Zeynep Çelik, Zeynep Oktay, Feyza Akçin Balan, Levent Şensoy, Feriştah Küçük, Elif Özge Damar Mıdık, Selda Sayın Kutlu, Şenay Elbasan Omar, Hatun Öztürk Çerik, Yelda Derviş, Serpil Erol
article en

Abstract

The aim of this study was to characterize invasive listeriosis in Türkiye and identify predictors of in-hospital mortality. This multicenter retrospective observational study included adult patients with laboratory-confirmed Listeria monocytogenes infection from 26 centers between 2015 and 2024. Clinical, demographic, laboratory, and treatment data were collected. Patients were classified based on infection type. Univariate analyses were followed by multivariable logistic regression to determine independent predictors of mortality. A total of 129 patients were included (mean age 62.1 ± 16.9 years; 65.9% male). The in-hospital mortality rate was 54.8%. Deceased patients were older and had more frequent comorbidities. Bacteremia without central nervous system involvement was more common among nonsurvivors. Lower Glasgow Coma Scale (GCS) scores, lower platelet counts, higher CRP levels, and more frequent blood culture positivity were observed in patients who died. In multivariable analyses, higher GCS scores were associated with lower odds of mortality (adjusted odds ratio [OR] 0.71 per 1-point increase, 95% confidence interval [CI] 0.59–0.86), as were higher platelet counts (adjusted OR: 0.94 per 10,000/µL increase, 95% CI: 0.89–0.99), whereas blood culture positivity was associated with higher odds of mortality (adjusted OR: 3.19, 95% CI: 1.04–9.82). Invasive listeriosis is associated with high mortality in Türkiye. Admission GCS score, platelet count, and blood culture positivity were independently associated with mortality and may help identify patients at increased risk of death.

Foodborne Pathogens and Disease
Sivas Cumhuriyet Üniversitesi (TR), Ministry of Health (TR), Koç University (TR), Ankara University (TR), Ondokuz Mayıs University (TR), Bezmiâlem Vakıf Üniversitesi (TR), Istanbul Medipol University (TR), Memorial Ankara Hospital (TR), Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR), Antalya Eğitim ve Araştırma Hastanesi (TR), Istanbul University-Cerrahpaşa (TR), Erzurum Regional Training and Research Hospital (TR), Education Training And Research (US), Haydarpaşa Numune Eğitim ve Araştırma Hastanesi (TR), Sağlık Bilimleri Üniversitesi (TR), Acıbadem University Atakent Hospital (TR), Şişli Etfal Eğitim ve Araştırma Hastanesi (TR), Ankara Etlik City Hospital (TR), Ankara Eğitim ve Araştırma Hastanesi (TR), Pamukkale University (TR), Ordu University (TR), Istanbul University (TR), University of Health Sciences Antigua (AG), Gazi University (TR)
Openalex Percentile: Top 20%
Listeria monocytogenes in Food Safety
DOISourceOpenAlex
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