Alkalizer-based gastroretentive floating tablets of amoxicillin for localized gastric delivery
INTRODUCTION: infection is a leading cause of peptic ulcer disease, yet amoxicillin trihydrate (AMX) efficacy is limited by its acid-catalyzed degradation and rapid gastric emptying. This study aimed to develop alkalizer-based gastroretentive floating tablets to enhance localized gastric-delivery and improve AMX stability under gastric conditions. MATERIALS AND METHODS: gastric retention in Sprague-Dawley rats. RESULTS: gastric retention. CONCLUSION: eradication.
Authors
- Hiba Asrar K
- Alan Raj (ORCID: https://orcid.org/0000-0002-2743-6686)
- Minil Mukundan
- Rajesh Sreedharan Nair (ORCID: https://orcid.org/0000-0002-8540-5044)
- Sreejith KR
- Angel Treasa Alex (ORCID: https://orcid.org/0000-0002-5793-6868)
- Sarath Chandran C (ORCID: https://orcid.org/0000-0002-8615-9092)
- Rahul Kundoolithodi (ORCID: https://orcid.org/0000-0003-3116-9610)
- Abhijith. K. Shaji
- Gopika Nath C
- Reshma K
Institutions
- University of Nottingham (GB)
- University of Nottingham Malaysia Campus (MY)
- Manipal Academy of Higher Education (IN)
- Kerala University of Health Sciences (IN)
- Kannur Medical College (IN)
Publication Details
- Journal
- Therapeutic Delivery
- Published
- 2026-10-18
- DOI
- https://doi.org/10.1080/20415990.2026.2742653
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00