One Hand Only: Chiral Fragmentation Control to Remove the Unwanted Mirror-Image Molecule in the Soai Reaction

Many molecules exist in two mirror-image forms, like left and right hands. Living thingsusually need only one of them. The 2026 Nobel Prize in Chemistry recognised two ideas thatexplain how one mirror-image form can take over a reaction: the nonlinear effect (Kagan) andautocatalysis (Soai). This note proposes a new area, Geometric Chemistry, which describessuch reactions with simple “maps” of conditions, much like a phase diagram. Our firstquestion is practical: how can we reduce the unwanted mirror-image molecule (R)to nearly zero? We treat it as an optimisation problem: choose the reaction conditionsthat minimise R subject to the limits of time, material and noise.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-18
DOI
https://doi.org/10.5281/zenodo.23445374
Primary Topic
Origins and Evolution of Life
Type
article
Field-Weighted Citation Impact
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article

One Hand Only: Chiral Fragmentation Control to Remove the Unwanted Mirror-Image Molecule in the Soai Reaction

DR. ZULFIQAR ALI KHAN
Zenodo (CERN European Organization for Nuclear Research)
Origins and Evolution of Life
article

One Hand Only: Chiral Fragmentation Control to Remove the Unwanted Mirror-Image Molecule in the Soai Reaction

DR. ZULFIQAR ALI KHAN
article en

Abstract

Many molecules exist in two mirror-image forms, like left and right hands. Living thingsusually need only one of them. The 2026 Nobel Prize in Chemistry recognised two ideas thatexplain how one mirror-image form can take over a reaction: the nonlinear effect (Kagan) andautocatalysis (Soai). This note proposes a new area, Geometric Chemistry, which describessuch reactions with simple “maps” of conditions, much like a phase diagram. Our firstquestion is practical: how can we reduce the unwanted mirror-image molecule (R)to nearly zero? We treat it as an optimisation problem: choose the reaction conditionsthat minimise R subject to the limits of time, material and noise.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 14%
Origins and Evolution of Life
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