Multiomics-driven advances in social and solitary wasp venom research: biological complexity and translational applications

Background and aim Social and solitary wasp venoms contain diverse bioactive molecules with ecological and biomedical significance. This review examines advances in understanding their composition, functions, and therapeutic potential through integrated multiomics approaches.Experimental approach Relevant literature search was identified through a structured search of Google Scholar, PubMed, and UniProtKB using predefined search terms. The literature identification and selection process was documented using a PRISMA-style flow diagram to improve transparency.Key findings Integrated multiomics approaches have markedly overcome the limitations of single-omics methods. These strategies have facilitated the identification of novel venom components and provided insights into their species-specific variations. Additionally, numerous bioactive compounds with antimicrobial, anticancer, anti-inflammatory, neuroprotective, and anticoagulant properties have also been identified through this approach.Conclusion Integrating multiomics with bioinformatics, high-throughput screening, and synthetic biology can accelerate venom-derived therapeutic discovery, optimization, and large-scale production. However, further functional validation and clinical studies remain necessary.