EVALUATION OF CENTRAL ASIAN AND REGIONAL VARIETIES OF MUMIJO ON HEMOSTATIC DYNAMICS AND WATER–ELECTROLYTE EXCRETION

Mumijo (Shilajit) is a natural herbo-mineral substance valued in traditional medicine for its rejuvenating and adaptogenic properties. This study evaluated the anticoagulant, fibrinolytic, and diuretic actions of various regional types of mumijo. In vitro and in vivo experimental protocols were conducted using rat, dog, and rabbit models to assess blood coagulation dynamics (via Lee-White clotting assays and thrombelastography) and renal function following treatment with Alai, Khamzaabad, Afghan, Indian, Chinese, and Transbaikal mumijo. Afghan, Alai, Indian, and Transbaikal varieties demonstrated significant, dose-dependent anticoagulant activity. In dogs, oral Alai mumijo (25 mg/kg) markedly prolonged blood clotting time (>900 s vs. 354 s baseline), recalcification time (149 s vs. 94 s), and thrombin time (72 s vs. 13 s), while increasing heparin tolerance and fibrinolytic activity without altering Factor V, Factor VII+X, or total protein levels. Chinese mumijo exhibited minimal hemostatic effect. Intravenous Khamzaabad mumijo (1–50 mg/kg) induced dose-dependent diuresis and natriuresis by reducing renal tubular reabsorption. Regional Central Asian, Afghan, Indian, and Transbaikal mumijo function as effective natural modulators of blood coagulation, clot degradation, and fluid-electrolyte balance.